Breast carcinoma with osteoclast-like giant cells: Morphological and ultrastructural studies of a case with review of the literature

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Breast carcinoma with osteoclast-like giant cells : Morphological and ultrastructural studies of a case with review of the literature. / Gjerdrum, L. M.; Lauridse, M. C.; Sørensen, F. B.

In: Breast, Vol. 10, No. 3, 2001, p. 231-236.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Gjerdrum, LM, Lauridse, MC & Sørensen, FB 2001, 'Breast carcinoma with osteoclast-like giant cells: Morphological and ultrastructural studies of a case with review of the literature', Breast, vol. 10, no. 3, pp. 231-236. https://doi.org/10.1054/brst.2000.0244

APA

Gjerdrum, L. M., Lauridse, M. C., & Sørensen, F. B. (2001). Breast carcinoma with osteoclast-like giant cells: Morphological and ultrastructural studies of a case with review of the literature. Breast, 10(3), 231-236. https://doi.org/10.1054/brst.2000.0244

Vancouver

Gjerdrum LM, Lauridse MC, Sørensen FB. Breast carcinoma with osteoclast-like giant cells: Morphological and ultrastructural studies of a case with review of the literature. Breast. 2001;10(3):231-236. https://doi.org/10.1054/brst.2000.0244

Author

Gjerdrum, L. M. ; Lauridse, M. C. ; Sørensen, F. B. / Breast carcinoma with osteoclast-like giant cells : Morphological and ultrastructural studies of a case with review of the literature. In: Breast. 2001 ; Vol. 10, No. 3. pp. 231-236.

Bibtex

@article{52d43ccaec2845cba8c98d4402c58069,
title = "Breast carcinoma with osteoclast-like giant cells: Morphological and ultrastructural studies of a case with review of the literature",
abstract = "Primary carcinoma with osteoclast-like giant cells is a very rare tumour of the female breast. The clinical course, histological, immunohistochemical and ultrastructural features of 61 cases of invasive duct carcinoma with osteoclast-like multinucleated giant cells (OMGCs) are reviewed and a new case is presented. The median patient age of all patients included in the review was 42 years, the tumour was located in the upper outer quadrant and the mammographic and gross findings were of a well-defined tumour of dark-brown colour, resembling a metastatic melanoma. Follow-up data in the literature have shown that 86% of patients with these tumours are still alive after 5 years. Histologically, these tumours are invasive ductal carcinomas with OMGCs next to the neoplastic glands and within their lumen. Signs of recent and past haemorrhage are ubiquitously present in the highly vascularized stroma. Immunohistochemical and ultrastructural studies have claimed a benign histiocytic nature of the OMGCs; they may represent a special type of polykaryon, distinct from both osteoclasts and inflammatory giant cells.",
author = "Gjerdrum, {L. M.} and Lauridse, {M. C.} and S{\o}rensen, {F. B.}",
year = "2001",
doi = "10.1054/brst.2000.0244",
language = "English",
volume = "10",
pages = "231--236",
journal = "Breast",
issn = "0960-9776",
publisher = "Churchill Livingstone",
number = "3",

}

RIS

TY - JOUR

T1 - Breast carcinoma with osteoclast-like giant cells

T2 - Morphological and ultrastructural studies of a case with review of the literature

AU - Gjerdrum, L. M.

AU - Lauridse, M. C.

AU - Sørensen, F. B.

PY - 2001

Y1 - 2001

N2 - Primary carcinoma with osteoclast-like giant cells is a very rare tumour of the female breast. The clinical course, histological, immunohistochemical and ultrastructural features of 61 cases of invasive duct carcinoma with osteoclast-like multinucleated giant cells (OMGCs) are reviewed and a new case is presented. The median patient age of all patients included in the review was 42 years, the tumour was located in the upper outer quadrant and the mammographic and gross findings were of a well-defined tumour of dark-brown colour, resembling a metastatic melanoma. Follow-up data in the literature have shown that 86% of patients with these tumours are still alive after 5 years. Histologically, these tumours are invasive ductal carcinomas with OMGCs next to the neoplastic glands and within their lumen. Signs of recent and past haemorrhage are ubiquitously present in the highly vascularized stroma. Immunohistochemical and ultrastructural studies have claimed a benign histiocytic nature of the OMGCs; they may represent a special type of polykaryon, distinct from both osteoclasts and inflammatory giant cells.

AB - Primary carcinoma with osteoclast-like giant cells is a very rare tumour of the female breast. The clinical course, histological, immunohistochemical and ultrastructural features of 61 cases of invasive duct carcinoma with osteoclast-like multinucleated giant cells (OMGCs) are reviewed and a new case is presented. The median patient age of all patients included in the review was 42 years, the tumour was located in the upper outer quadrant and the mammographic and gross findings were of a well-defined tumour of dark-brown colour, resembling a metastatic melanoma. Follow-up data in the literature have shown that 86% of patients with these tumours are still alive after 5 years. Histologically, these tumours are invasive ductal carcinomas with OMGCs next to the neoplastic glands and within their lumen. Signs of recent and past haemorrhage are ubiquitously present in the highly vascularized stroma. Immunohistochemical and ultrastructural studies have claimed a benign histiocytic nature of the OMGCs; they may represent a special type of polykaryon, distinct from both osteoclasts and inflammatory giant cells.

UR - http://www.scopus.com/inward/record.url?scp=0034983352&partnerID=8YFLogxK

U2 - 10.1054/brst.2000.0244

DO - 10.1054/brst.2000.0244

M3 - Journal article

AN - SCOPUS:0034983352

VL - 10

SP - 231

EP - 236

JO - Breast

JF - Breast

SN - 0960-9776

IS - 3

ER -

ID: 375144748