Janne and Meritxell at SIAM Life Sciences

Janne and Meritxell are participating in the conference "SIAM conference on the Life Sciences", Boston, July 11-14.

Janne is giving a talk with title "Signs of Sensitivities in Post-Translational Modification Systems" and abstract: "Sensitivity analysis in chemical reaction networks comprises studying the effect that a slight perturbation exerts on the concentration of the species of the network at steady state. For instance, such a perturbation could be the addition of a small amount of one of the chemicals of the network. We want to predict the change in the concentrations of the other chemicals, after the system's return to a steady state. This information is often used for model discrimination. Since most kinetic parameters are very poorly characterized, it is often not realistic to predict the exact effects. Therefore, the goal is to predict the sign of sensitivities, i.e., which concentrations increase and which concentrations decrease as a result of the perturbation. In this talk I will show some results on the prediction of these signs, mainly focusing on post-translational modification systems. This talk is based on joint work with Elisenda Feliu."

The talk is part of the mini-symposium "Mathematical Analysis of Biochemical Reaction Networks"