Familial disease history and fur color type are associated with urinary tract disease in farmed mink (Neovison vison)
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Familial disease history and fur color type are associated with urinary tract disease in farmed mink (Neovison vison). / Mundbjerg, Karin; Tolver, Anders; Sebbelov, Ida; Clausen, Tove; Lundfold, Jesper; Hammer, Anne Sofie.
I: Research in Veterinary Science, Bind 133, 2020, s. 326-331.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - Familial disease history and fur color type are associated with urinary tract disease in farmed mink (Neovison vison)
AU - Mundbjerg, Karin
AU - Tolver, Anders
AU - Sebbelov, Ida
AU - Clausen, Tove
AU - Lundfold, Jesper
AU - Hammer, Anne Sofie
PY - 2020
Y1 - 2020
N2 - Mink urinary tract disease (MUTD) and mink fatty liver disease (MFLD) constitute two important disease entities in the mink production associated with sudden mortality and economic loss. Genetic factors or heritability of the diseases have not previously been investigated. Since mortality associated with MUTD and MFLD mainly occurs in the young immature mink, a potential genetic predisposition would rarely be passed on by the mink itself but potentially by relatives. This study aimed to investigate familial aggregation of MUTD and MFLD based on data from four generations of mink on a research farm. The study included a total of 27,511 mink of brown and black color type with a post mortem prevalence of 0.8% for MUTD (n = 221) and 0.5% for MFLD (n = 138) within a year from birth. The prevalence in the color types brown and black were 0.6% and 1.6% for MUTD and 0.5% and 0.7% for MFLD. Family history of MUTD in breeding animals was found to be associated with a significantly higher probability of MUTD leading to mortality in offspring (p = 0.012, RR = 1.7; CI [1.1–2.4]), however this association was not significant for MFLD (p = 0.163, RR = 1.5; CI [0.9–2.7]). Mink of the color type black showed significantly higher risk of MUTD (RR = 2.6; CI [2.0–3.3]) and MFLD (R = 1.6; CI [1.1–2.2]) compared to brown mink. The results indicate that genetic factors may play a role in understanding MUTD and that selective breeding may contribute to reduce mortalities associated with this disease.
AB - Mink urinary tract disease (MUTD) and mink fatty liver disease (MFLD) constitute two important disease entities in the mink production associated with sudden mortality and economic loss. Genetic factors or heritability of the diseases have not previously been investigated. Since mortality associated with MUTD and MFLD mainly occurs in the young immature mink, a potential genetic predisposition would rarely be passed on by the mink itself but potentially by relatives. This study aimed to investigate familial aggregation of MUTD and MFLD based on data from four generations of mink on a research farm. The study included a total of 27,511 mink of brown and black color type with a post mortem prevalence of 0.8% for MUTD (n = 221) and 0.5% for MFLD (n = 138) within a year from birth. The prevalence in the color types brown and black were 0.6% and 1.6% for MUTD and 0.5% and 0.7% for MFLD. Family history of MUTD in breeding animals was found to be associated with a significantly higher probability of MUTD leading to mortality in offspring (p = 0.012, RR = 1.7; CI [1.1–2.4]), however this association was not significant for MFLD (p = 0.163, RR = 1.5; CI [0.9–2.7]). Mink of the color type black showed significantly higher risk of MUTD (RR = 2.6; CI [2.0–3.3]) and MFLD (R = 1.6; CI [1.1–2.2]) compared to brown mink. The results indicate that genetic factors may play a role in understanding MUTD and that selective breeding may contribute to reduce mortalities associated with this disease.
KW - Cystitis
KW - Familial aggregation
KW - Hepatic steatosis
KW - Mink
KW - Neovison vison
KW - Urolithiasis
U2 - 10.1016/j.rvsc.2020.10.026
DO - 10.1016/j.rvsc.2020.10.026
M3 - Journal article
C2 - 33172618
AN - SCOPUS:85095803367
VL - 133
SP - 326
EP - 331
JO - Research in Veterinary Science
JF - Research in Veterinary Science
SN - 0034-5288
ER -
ID: 251586255