Modelling the contribution of family history and variation in single nucleotide polymorphisms to risk of schizophrenia: a Danish national birth cohort-based study
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Modelling the contribution of family history and variation in single nucleotide polymorphisms to risk of schizophrenia : a Danish national birth cohort-based study. / Agerbo, Esben; Mortensen, Preben Bo; Wiuf, Carsten; Pedersen, Michael S; McGrath, John; Hollegaard, Mads Vilhelm; Nørgaard-Pedersen, Bent; Hougaard, David M; Mors, Ole; Pedersen, Carsten B.
I: Schizophrenia Research, Bind 134, Nr. 2-3, 2012, s. 246-252.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Modelling the contribution of family history and variation in single nucleotide polymorphisms to risk of schizophrenia
T2 - a Danish national birth cohort-based study
AU - Agerbo, Esben
AU - Mortensen, Preben Bo
AU - Wiuf, Carsten
AU - Pedersen, Michael S
AU - McGrath, John
AU - Hollegaard, Mads Vilhelm
AU - Nørgaard-Pedersen, Bent
AU - Hougaard, David M
AU - Mors, Ole
AU - Pedersen, Carsten B
N1 - Copyright © 2011 Elsevier B.V. All rights reserved.
PY - 2012
Y1 - 2012
N2 - Epidemiological studies indicate that having any family member with schizophrenia increases the risk of schizophrenia in the probands. However, genome-wide association studies (GWAS) have accounted for little of this variation. The aim of this study was to use a population-based sample to explore the influence of single-nucleotide polymorphisms (SNPs) on the excess schizophrenia risk in offspring of parents with a psychotic, bipolar affective or other psychiatric disorder.
AB - Epidemiological studies indicate that having any family member with schizophrenia increases the risk of schizophrenia in the probands. However, genome-wide association studies (GWAS) have accounted for little of this variation. The aim of this study was to use a population-based sample to explore the influence of single-nucleotide polymorphisms (SNPs) on the excess schizophrenia risk in offspring of parents with a psychotic, bipolar affective or other psychiatric disorder.
KW - Cohort Studies
KW - Community Health Planning
KW - Denmark
KW - Family Health
KW - Female
KW - Genetic Predisposition to Disease
KW - Genetics, Population
KW - Genome-Wide Association Study
KW - Humans
KW - Male
KW - Polymorphism, Single Nucleotide
KW - Psychotic Disorders
KW - Risk
KW - Schizophrenia
U2 - 10.1016/j.schres.2011.10.025
DO - 10.1016/j.schres.2011.10.025
M3 - Journal article
C2 - 22108675
VL - 134
SP - 246
EP - 252
JO - Schizophrenia Research
JF - Schizophrenia Research
SN - 0920-9964
IS - 2-3
ER -
ID: 40763541