Appraisal of triglyceride-related markers as early predictors of metabolic outcomes in the PREVIEW lifestyle intervention: A controlled post-hoc trial
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Appraisal of triglyceride-related markers as early predictors of metabolic outcomes in the PREVIEW lifestyle intervention: A controlled post-hoc trial. / Navas-Carretero, Santiago; San-Cristobal, Rodrigo; Vestentoft, Pia Siig; Brand-Miller, Jennie C.; Jalo, Elli; Westerterp-Plantenga, Margriet; Simpson, Elizabeth J; Handjieva-Darlenska, Teodora; Stratton, Gareth; Huttunen-Lenz, Maija; Lam, Tony; Muirhead, Roslyn; Poppitt, Sally; Pietiläinen, Kirsi H; Adam, Tanja; Taylor, Moira A; Handjiev, Svetoslav; McNarry, Melitta A; Hansen, Sylvia; Brodie, Shannon; Silvestre, Marta P; Macdonald, Ian A; Boyadjieva, Nadka; Mackintosh, Kelly A; Schlicht, Wolfgang; Liu, Amy; Larsen, Thomas Meinert; Fogelholm, Mikael; Raben, Anne; Martinez, J Alfredo.
I: Frontiers in Nutrition, Bind 8, 733697, 2021.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Appraisal of triglyceride-related markers as early predictors of metabolic outcomes in the PREVIEW lifestyle intervention: A controlled post-hoc trial
AU - Navas-Carretero, Santiago
AU - San-Cristobal, Rodrigo
AU - Vestentoft, Pia Siig
AU - Brand-Miller, Jennie C.
AU - Jalo, Elli
AU - Westerterp-Plantenga, Margriet
AU - Simpson, Elizabeth J
AU - Handjieva-Darlenska, Teodora
AU - Stratton, Gareth
AU - Huttunen-Lenz, Maija
AU - Lam, Tony
AU - Muirhead, Roslyn
AU - Poppitt, Sally
AU - Pietiläinen, Kirsi H
AU - Adam, Tanja
AU - Taylor, Moira A
AU - Handjiev, Svetoslav
AU - McNarry, Melitta A
AU - Hansen, Sylvia
AU - Brodie, Shannon
AU - Silvestre, Marta P
AU - Macdonald, Ian A
AU - Boyadjieva, Nadka
AU - Mackintosh, Kelly A
AU - Schlicht, Wolfgang
AU - Liu, Amy
AU - Larsen, Thomas Meinert
AU - Fogelholm, Mikael
AU - Raben, Anne
AU - Martinez, J Alfredo
N1 - CURIS 2021 NEXS 340
PY - 2021
Y1 - 2021
N2 - Background: Individuals with pre-diabetes are commonly overweight andbenefit from dietary and physical activity strategies aimed at decreasing body weight and hyperglycemia. Early insulin resistance can be estimated via the triglyceride glucose index {TyG = Ln [TG (mg/dl) × fasting plasma glucose (FPG) (mg/dl)/2]} and the hypertriglyceridemic-high waist phenotype (TyG-waist), based on TyG x waist circumference (WC) measurements. Both indices may be useful for implementing personalized metabolic management. In this secondary analysis of a randomized controlled trial (RCT), we aimed to determine whether the differences in baseline TyG values and TyG-waist phenotype predicted individual responses to type-2 diabetes (T2D) prevention programs.Methods: The present post-hoc analyses were conducted within the Prevention of Diabetes through Lifestyle intervention and population studies in Europe and around the world (PREVIEW) study completers (n = 899), a multi-center RCT conducted in eight countries (NCT01777893). The study aimed to reduce the incidence of T2D in a population with pre-diabetes during a 3-year randomized intervention with two sequential phases. The first phase was a 2-month weight loss intervention to achieve ≥8% weight loss. The second phase was a 34-month weight loss maintenance intervention with two diets providing different amounts of protein and different glycemic indices, and two physical activity programs with different exercise intensities in a 2 x 2 factorial design. On investigation days, we assessed anthropometrics, glucose/lipid metabolism markers,and diet and exercise questionnaires under standardized procedures.Results: Diabetes-related markers improved during all four lifestyle interventions. Higher baseline TyG index (p < 0.001) was associated with greater reductions in body weight, fasting glucose, and triglyceride (TG), while a high TyG-waist phenotype predicted better TG responses, particularly in those randomized to physical activity (PA) of moderate intensity.Conclusions: Two novel indices of insulin resistance (TyG and TyG-waist) may allow for a more personalized approach to avoiding progression to T2D.Clinical Trial Registration: https://clinicaltrials.gov/ct2/show/NCT01777893reference, identifier: NCT01777893.
AB - Background: Individuals with pre-diabetes are commonly overweight andbenefit from dietary and physical activity strategies aimed at decreasing body weight and hyperglycemia. Early insulin resistance can be estimated via the triglyceride glucose index {TyG = Ln [TG (mg/dl) × fasting plasma glucose (FPG) (mg/dl)/2]} and the hypertriglyceridemic-high waist phenotype (TyG-waist), based on TyG x waist circumference (WC) measurements. Both indices may be useful for implementing personalized metabolic management. In this secondary analysis of a randomized controlled trial (RCT), we aimed to determine whether the differences in baseline TyG values and TyG-waist phenotype predicted individual responses to type-2 diabetes (T2D) prevention programs.Methods: The present post-hoc analyses were conducted within the Prevention of Diabetes through Lifestyle intervention and population studies in Europe and around the world (PREVIEW) study completers (n = 899), a multi-center RCT conducted in eight countries (NCT01777893). The study aimed to reduce the incidence of T2D in a population with pre-diabetes during a 3-year randomized intervention with two sequential phases. The first phase was a 2-month weight loss intervention to achieve ≥8% weight loss. The second phase was a 34-month weight loss maintenance intervention with two diets providing different amounts of protein and different glycemic indices, and two physical activity programs with different exercise intensities in a 2 x 2 factorial design. On investigation days, we assessed anthropometrics, glucose/lipid metabolism markers,and diet and exercise questionnaires under standardized procedures.Results: Diabetes-related markers improved during all four lifestyle interventions. Higher baseline TyG index (p < 0.001) was associated with greater reductions in body weight, fasting glucose, and triglyceride (TG), while a high TyG-waist phenotype predicted better TG responses, particularly in those randomized to physical activity (PA) of moderate intensity.Conclusions: Two novel indices of insulin resistance (TyG and TyG-waist) may allow for a more personalized approach to avoiding progression to T2D.Clinical Trial Registration: https://clinicaltrials.gov/ct2/show/NCT01777893reference, identifier: NCT01777893.
KW - Faculty of Science
KW - Obesity
KW - Pre-diabetes
KW - Triglycerides (PubChem CID: 5460048)
KW - Hypertriglyceridemic-waist phenotype
KW - Precision nutrition
KW - Diabetes
KW - Carbohydrate metabolism
KW - Lipid markers
U2 - 10.3389/fnut.2021.733697
DO - 10.3389/fnut.2021.733697
M3 - Journal article
C2 - 34790686
VL - 8
JO - Frontiers in Nutrition
JF - Frontiers in Nutrition
SN - 2296-861X
M1 - 733697
ER -
ID: 284422807