Changes in circulating metabolites during weight loss and weight loss maintenance in relation to cardiometabolic risk
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Changes in circulating metabolites during weight loss and weight loss maintenance in relation to cardiometabolic risk. / Papandreou, Christopher; Harrold, Joanne A; Hansen, Thea Toft; Halford, Jason C G; Sjödin, Anders Mikael; Bulló, Mònica.
I: Nutrients, Bind 13, Nr. 12, 4289, 2021.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Changes in circulating metabolites during weight loss and weight loss maintenance in relation to cardiometabolic risk
AU - Papandreou, Christopher
AU - Harrold, Joanne A
AU - Hansen, Thea Toft
AU - Halford, Jason C G
AU - Sjödin, Anders Mikael
AU - Bulló, Mònica
N1 - CURIS 2021 NEXS 388
PY - 2021
Y1 - 2021
N2 - Background: There is a substantial lack of knowledge of the biochemical mechanisms by which weight loss and weight regain exert their beneficial and adverse effects, respectively, on cardiometabolic outcomes. We examined associations between changes in circulating metabolites and changes in cardiometabolic risk factors during diet-induced weight loss and weight loss maintenance. Methods: This prospective analysis of data from the Satiety Innovation (SATIN) study involved adults living with overweight and obesity (mean age=47.5). One hundred sixty-two subjects achieving ≥8% weight loss during an initial 8-week low-calorie diet (LCD) were included in a 12-week weight loss maintenance period. Circulating metabolites (m=123) were profiled using a targeted multiplatform approach. Data were analyzed using multivariate linear regression models. Results: Decreases in the concentrations of several phosphatidylcholines (PCs), sphingomyelins (SMs), and valine were consistently associated with decreases in total (TChol) and low-density lipoprotein cholesterol (LDL-C) levels during the LCD. Increases in PCs and SMs were significantly associated with increases in TChol and LDL-C during the weight loss maintenance period. Decreases and increases in PCs during LCD and maintenance period, respectively, were associated with decreases in the levels of triglycerides. Conclusions: The results of this study suggest that decreases in circulating PCs and SMs during weight loss and the subsequent weight loss maintenance period may decrease the cardiovascular risk through impacting TChol and LDL-C.
AB - Background: There is a substantial lack of knowledge of the biochemical mechanisms by which weight loss and weight regain exert their beneficial and adverse effects, respectively, on cardiometabolic outcomes. We examined associations between changes in circulating metabolites and changes in cardiometabolic risk factors during diet-induced weight loss and weight loss maintenance. Methods: This prospective analysis of data from the Satiety Innovation (SATIN) study involved adults living with overweight and obesity (mean age=47.5). One hundred sixty-two subjects achieving ≥8% weight loss during an initial 8-week low-calorie diet (LCD) were included in a 12-week weight loss maintenance period. Circulating metabolites (m=123) were profiled using a targeted multiplatform approach. Data were analyzed using multivariate linear regression models. Results: Decreases in the concentrations of several phosphatidylcholines (PCs), sphingomyelins (SMs), and valine were consistently associated with decreases in total (TChol) and low-density lipoprotein cholesterol (LDL-C) levels during the LCD. Increases in PCs and SMs were significantly associated with increases in TChol and LDL-C during the weight loss maintenance period. Decreases and increases in PCs during LCD and maintenance period, respectively, were associated with decreases in the levels of triglycerides. Conclusions: The results of this study suggest that decreases in circulating PCs and SMs during weight loss and the subsequent weight loss maintenance period may decrease the cardiovascular risk through impacting TChol and LDL-C.
KW - Adult
KW - Aged
KW - Body Mass Index
KW - Body Weight Maintenance/physiology
KW - Caloric Restriction
KW - Cardiometabolic Risk Factors
KW - Cholesterol/blood
KW - Cholesterol, LDL/blood
KW - Female
KW - Humans
KW - Linear Models
KW - Male
KW - Middle Aged
KW - Obesity/blood
KW - Phosphatidylcholines/blood
KW - Prospective Studies
KW - Satiation
KW - Sphingomyelins/blood
KW - Triglycerides/blood
KW - Valine/blood
KW - Weight Loss/physiology
KW - Young Adult
KW - Faculty of Science
KW - Metabolomics
KW - Cardiometabolic risk
KW - Weight loss
KW - Weight maintenance
KW - SATIN
U2 - 10.3390/nu13124289
DO - 10.3390/nu13124289
M3 - Journal article
C2 - 34959840
VL - 13
JO - Nutrients
JF - Nutrients
SN - 2072-6643
IS - 12
M1 - 4289
ER -
ID: 291014131