Prolonged and persistent diarrhoea is not restricted to children with acute malnutrition: An observational study in Ethiopia
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Prolonged and persistent diarrhoea is not restricted to children with acute malnutrition : An observational study in Ethiopia. / Zangenberg, Mike; Johansen, Øystein H; Abdissa, Alemseged; Eshetu, Beza; Kurtzhals, Jørgen; Friis, Henrik; Sommerfelt, Halvor; Langeland, Nina; Hanevik, Kurt.
I: Tropical Medicine & International Health, Bind 24, Nr. 9, 2019, s. 1088-1097.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Prolonged and persistent diarrhoea is not restricted to children with acute malnutrition
T2 - An observational study in Ethiopia
AU - Zangenberg, Mike
AU - Johansen, Øystein H
AU - Abdissa, Alemseged
AU - Eshetu, Beza
AU - Kurtzhals, Jørgen
AU - Friis, Henrik
AU - Sommerfelt, Halvor
AU - Langeland, Nina
AU - Hanevik, Kurt
N1 - CURIS 2019 NEXS 268 This article is protected by copyright. All rights reserved.
PY - 2019
Y1 - 2019
N2 - Objectives: To assess the prevalence of prolonged and persistent diarrhoea, to estimate their co-occurrence with acute malnutrition and association with demographic and clinical factors.Methods: Case-control study where cases were children under 5 years of age with diarrhoea and controls were children without diarrhoea, frequency-matched weekly by age and district of residency. Controls for cases 0-11 months were recruited from vaccination rooms and controls for cases 12-59 months were recruited by house visits using random locations in the catchment area of the study sites. Data were analysed by mixed model logistic regression.Results: We enrolled 1134 cases and 946 controls. Among the cases, 967 (85%) had acute diarrhoea (AD), 129 (11%) had ProD and 36 (3.2%) had PD. More cases had acute malnutrition at enrolment (17% vs 4%, p<0.0001) and more were born prematurely (5.7% vs 1.8%, p<0.0001) than controls. 75% of ProPD cases did not have acute malnutrition. Cases with AD and ProPD had different symptomatology, even beyond illness duration.Conclusions: ProPD is common among children presenting with diarrhoea and is not confined to children with acute malnutrition. There is an urgent need for studies assessing causes of ProPD with and without acute malnutrition to develop treatment guidelines for these conditions.
AB - Objectives: To assess the prevalence of prolonged and persistent diarrhoea, to estimate their co-occurrence with acute malnutrition and association with demographic and clinical factors.Methods: Case-control study where cases were children under 5 years of age with diarrhoea and controls were children without diarrhoea, frequency-matched weekly by age and district of residency. Controls for cases 0-11 months were recruited from vaccination rooms and controls for cases 12-59 months were recruited by house visits using random locations in the catchment area of the study sites. Data were analysed by mixed model logistic regression.Results: We enrolled 1134 cases and 946 controls. Among the cases, 967 (85%) had acute diarrhoea (AD), 129 (11%) had ProD and 36 (3.2%) had PD. More cases had acute malnutrition at enrolment (17% vs 4%, p<0.0001) and more were born prematurely (5.7% vs 1.8%, p<0.0001) than controls. 75% of ProPD cases did not have acute malnutrition. Cases with AD and ProPD had different symptomatology, even beyond illness duration.Conclusions: ProPD is common among children presenting with diarrhoea and is not confined to children with acute malnutrition. There is an urgent need for studies assessing causes of ProPD with and without acute malnutrition to develop treatment guidelines for these conditions.
KW - Faculty of Science
KW - Prolonged diarrhoea
KW - Persistent diarrhoea
KW - Moderate acute malnutrition
KW - Severe acute malnutrition
U2 - 10.1111/tmi.13291
DO - 10.1111/tmi.13291
M3 - Journal article
C2 - 31325406
VL - 24
SP - 1088
EP - 1097
JO - Tropical Medicine & International Health
JF - Tropical Medicine & International Health
SN - 1360-2276
IS - 9
ER -
ID: 224898374