Animal models of obesity and diabetes mellitus
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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Animal models of obesity and diabetes mellitus. / Kleinert, Maximilian; Clemmensen, Christoffer; Hofmann, Susanna M; Moore, Mary C; Renner, Simone; Woods, Stephen C; Huypens, Peter; Beckers, Johannes; de Angelis, Martin Hrabe; Schürmann, Annette; Bakhti, Mostafa; Klingenspor, Martin; Heiman, Mark; Cherrington, Alan D; Ristow, Michael; Lickert, Heiko; Wolf, Eckhard; Havel, Peter J; Müller, Timo D; Tschöp, Matthias H.
I: Nature Reviews Endocrinology, Bind 14, 2018, s. 140-162.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - Animal models of obesity and diabetes mellitus
AU - Kleinert, Maximilian
AU - Clemmensen, Christoffer
AU - Hofmann, Susanna M
AU - Moore, Mary C
AU - Renner, Simone
AU - Woods, Stephen C
AU - Huypens, Peter
AU - Beckers, Johannes
AU - de Angelis, Martin Hrabe
AU - Schürmann, Annette
AU - Bakhti, Mostafa
AU - Klingenspor, Martin
AU - Heiman, Mark
AU - Cherrington, Alan D
AU - Ristow, Michael
AU - Lickert, Heiko
AU - Wolf, Eckhard
AU - Havel, Peter J
AU - Müller, Timo D
AU - Tschöp, Matthias H
N1 - CURIS 2018 NEXS 078
PY - 2018
Y1 - 2018
N2 - More than one-third of the worldwide population is overweight or obese and therefore at risk of developing type 2 diabetes mellitus. In order to mitigate this pandemic, safer and more potent therapeutics are urgently required. This necessitates the continued use of animal models to discover, validate and optimize novel therapeutics for their safe use in humans. In order to improve the transition from bench to bedside, researchers must not only carefully select the appropriate model but also draw the right conclusions. In this Review, we consolidate the key information on the currently available animal models of obesity and diabetes and highlight the advantages, limitations and important caveats of each of these models.
AB - More than one-third of the worldwide population is overweight or obese and therefore at risk of developing type 2 diabetes mellitus. In order to mitigate this pandemic, safer and more potent therapeutics are urgently required. This necessitates the continued use of animal models to discover, validate and optimize novel therapeutics for their safe use in humans. In order to improve the transition from bench to bedside, researchers must not only carefully select the appropriate model but also draw the right conclusions. In this Review, we consolidate the key information on the currently available animal models of obesity and diabetes and highlight the advantages, limitations and important caveats of each of these models.
KW - Faculty of Science
KW - Experimental models of disease
KW - Obesity
KW - Type 1 diabetes
KW - Type 2 diabetes
U2 - 10.1038/nrendo.2017.161
DO - 10.1038/nrendo.2017.161
M3 - Review
C2 - 29348476
VL - 14
SP - 140
EP - 162
JO - Nature Reviews Endocrinology
JF - Nature Reviews Endocrinology
SN - 1759-5029
ER -
ID: 190702705