Association between serum vitamin D metabolites and metabolic function in healthy Asian adults
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Dokumenter
- Ding et al_Nutrients_2020_Vol 12(12)_e3706
Forlagets udgivne version, 902 KB, PDF-dokument
The association between low vitamin D status and the development of type 2 diabetes mellitus is well established; however, intervention trials that increased serum vitamin D (through ultraviolet B exposure or dietary supplementation) provide mixed outcomes. Recent evidence suggests that metabolites directly related to vitamin D receptor activation-1α,25-dihydroxyvitamin D3 and 24R,25-dihydroxyvitamin D3-may be better markers of vitamin D repletion status. We tested the hypothesis that a vitamin D metabolite (VDM) index, calculated as the sum of normalized fasting serum concentrations of 1α,25-dihydroxyvitamin D3 and 24R,25-dihydroxyvitamin D3, is associated with metabolic function. We measured subcutaneous and visceral adipose tissue volume, intrahepatic triglyceride content, maximum oxygen uptake, insulin sensitivity (4 h hyperinsulinemic-euglycemic clamp), and insulin secretion (3 h meal tolerance test with mathematical modeling) and calculated the VDM index in 65 healthy Asian adults. Subjects with a low VDM index had lower peripheral insulin sensitivity and beta-cell function compared to subjects with a high VDM index (both p < 0.05), matched for age, sex, BMI, and serum 25-hydroxyvitamin D3. Serum 25-hydroxyvitamin D3 was not associated with peripheral insulin sensitivity or beta-cell function. Our results suggest that, rather than enhancing vitamin D substrate availability, upregulation of vitamin D action is more likely to lead to improvements in glucose homeostasis.
Originalsprog | Engelsk |
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Artikelnummer | 3706 |
Tidsskrift | Nutrients |
Vol/bind | 12 |
Udgave nummer | 12 |
Antal sider | 10 |
ISSN | 2072-6643 |
DOI | |
Status | Udgivet - 2020 |
Bibliografisk note
CURIS 2020 NEXS 363
- Det Natur- og Biovidenskabelige Fakultet
Forskningsområder
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