Statement on the safety of EstroG-100TM as a novel food pursuant to Regulation (EC) No 258/97
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Rådgivning › fagfællebedømt
Standard
Statement on the safety of EstroG-100TM as a novel food pursuant to Regulation (EC) No 258/97. / EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA).
I: E F S A Journal, Bind 15, Nr. 5, 4778, 08.05.2017.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Rådgivning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Statement on the safety of EstroG-100TM as a novel food pursuant to Regulation (EC) No 258/97
AU - EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA)
AU - Sjödin, Anders Mikael
N1 - EFSA 2017 4778
PY - 2017/5/8
Y1 - 2017/5/8
N2 - Following a request from the European Commission, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to update its scientific opinion on the safety of EstroG-100TM as a novel food (NF) in the light of additional information submitted by the applicant. In its previous scientific opinion of 2016, the Panel concluded that EstroG-100TM, which is a hot-water extract of a mixture of three herbal roots, is safe for the use in food supplements at the maximum intake level of 175 mg/day in post-menopausal women, which is lower than the maximum intake level proposed by the applicant (514 mg/day). The Panel reached its conclusions based on the effects of EstroG-100TM on liver and haematology as observed in several oral toxicity studies, the lack of information on liver and haematological parameters in human studies and the absence of chronic toxicity data. In view of the Panel’s conclusion on the safety of EstroG-100TM, the applicant has now provided additional information on haematological and liver parameters for the human intervention study with EstroG-100TM and historical control data related to the subchronic 90-day oral toxicity study with EstroG-100TM. After assessing the additional information provided by the applicant, the Panel considers that the conclusion of the scientific opinion on the safety of EstroG-100TM does not need to be revised, and thus, the Panel reconfirms that the NF is safe for the use in food supplements at the maximum intake level of 175 mg/day in post-menopausal women.
AB - Following a request from the European Commission, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to update its scientific opinion on the safety of EstroG-100TM as a novel food (NF) in the light of additional information submitted by the applicant. In its previous scientific opinion of 2016, the Panel concluded that EstroG-100TM, which is a hot-water extract of a mixture of three herbal roots, is safe for the use in food supplements at the maximum intake level of 175 mg/day in post-menopausal women, which is lower than the maximum intake level proposed by the applicant (514 mg/day). The Panel reached its conclusions based on the effects of EstroG-100TM on liver and haematology as observed in several oral toxicity studies, the lack of information on liver and haematological parameters in human studies and the absence of chronic toxicity data. In view of the Panel’s conclusion on the safety of EstroG-100TM, the applicant has now provided additional information on haematological and liver parameters for the human intervention study with EstroG-100TM and historical control data related to the subchronic 90-day oral toxicity study with EstroG-100TM. After assessing the additional information provided by the applicant, the Panel considers that the conclusion of the scientific opinion on the safety of EstroG-100TM does not need to be revised, and thus, the Panel reconfirms that the NF is safe for the use in food supplements at the maximum intake level of 175 mg/day in post-menopausal women.
KW - Faculty of Science
KW - EstroG-100TM
KW - Cynanchum wilfordii
KW - Phlomis umbrosa
KW - Angelica gigas
KW - Novel food
KW - Safety
U2 - 10.2903/j.efsa.2017.4778
DO - 10.2903/j.efsa.2017.4778
M3 - Journal article
VL - 15
JO - E F S A Journal
JF - E F S A Journal
SN - 1831-4732
IS - 5
M1 - 4778
ER -
ID: 188451726