Targeted-plasticity in the corticospinal tract after human spinal cord injury
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
Standard
Targeted-plasticity in the corticospinal tract after human spinal cord injury. / Christiansen, Lasse; Perez, Monica A.
I: Neurotherapeutics, Bind 15, Nr. 3, 2018, s. 618-627.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Targeted-plasticity in the corticospinal tract after human spinal cord injury
AU - Christiansen, Lasse
AU - Perez, Monica A
PY - 2018
Y1 - 2018
N2 - Spinal cord injury (SCI) often results in impaired or absent sensorimotor function below the level of the lesion. Recent electrophysiological studies in humans with chronic incomplete SCI demonstrate that voluntary motor output can be to some extent potentiated by noninvasive stimulation that targets the corticospinal tract. We discuss emerging approaches that use transcranial magnetic stimulation (TMS) over the primary motor cortex and electrical stimulation over a peripheral nerve as tools to induce plasticity in residual corticospinal projections. A single TMS pulse over the primary motor cortex has been paired with peripheral nerve electrical stimulation at precise interstimulus intervals to reinforce corticospinal synaptic transmission using principles of spike-timing dependent plasticity. Pairs of TMS pulses have also been used at interstimulus intervals that mimic the periodicity of descending indirect (I) waves volleys in the corticospinal tract. This data, along with information about the extent of the injury, provides a new framework for exploring the contribution of the corticospinal tract to recovery of function following SCI.
AB - Spinal cord injury (SCI) often results in impaired or absent sensorimotor function below the level of the lesion. Recent electrophysiological studies in humans with chronic incomplete SCI demonstrate that voluntary motor output can be to some extent potentiated by noninvasive stimulation that targets the corticospinal tract. We discuss emerging approaches that use transcranial magnetic stimulation (TMS) over the primary motor cortex and electrical stimulation over a peripheral nerve as tools to induce plasticity in residual corticospinal projections. A single TMS pulse over the primary motor cortex has been paired with peripheral nerve electrical stimulation at precise interstimulus intervals to reinforce corticospinal synaptic transmission using principles of spike-timing dependent plasticity. Pairs of TMS pulses have also been used at interstimulus intervals that mimic the periodicity of descending indirect (I) waves volleys in the corticospinal tract. This data, along with information about the extent of the injury, provides a new framework for exploring the contribution of the corticospinal tract to recovery of function following SCI.
KW - Faculty of Science
KW - Noninvasive brain stimulation
KW - Physiology of magnetic stimulation
KW - Spinal cord injury
KW - Rehabilitation
KW - Spinal plasticity
U2 - 10.1007/s13311-018-0639-y
DO - 10.1007/s13311-018-0639-y
M3 - Review
C2 - 29946981
VL - 15
SP - 618
EP - 627
JO - Neurotherapeutics
JF - Neurotherapeutics
SN - 1933-7213
IS - 3
ER -
ID: 213042614